Depression (including severe forms) is a common disease that leads to the adverse consequences in social life as well as in personal life of a patient. Usually depression has a stabile nature and has a tendency to the backsets that affects the quality of life of the patient and his family. Heebie jeebies is the fourth among the leading causes of the population’s director disability in the world, and, maybe, – the second in the last 20 years.
Pharmacological help for the depressive disorders has advanced considerably since the early 60-ies of the XXth century, when the tricyclic antidepressants were developed for the first time. The constant search for more effective medicines and therapies has led to the appearance of the new groups of antidepressants and homeopathic solutions, to sharp increase of their brands in the pharmaceutical market. So, today the doctors and their patients are difficult to make the right choice in favor of this or that preparation.
Desyrel. What is the preparation?
Desyrel. The chemical formula
Desyrel is an antidepressant. The preparation has an antidepressant effect preferentially, with some sedative and anxiolytic effect.
Desyrel has a rapid impact on the psychic (affective tension, irritability, anxiety, insomnia) and the somatic symptoms of anxiety (palpitations, headache, muscle pain, frequent urination, sweating and hyperventilation).
The medicine is effective in the treatment of the sleep disorder in the patients with depression. The medicine stimulates the depth and duration of sleep, recovers its physiological structure and quality.
Desyrel stabilizes the emotional state, improves mood and reduces the morbid tendency to alcohol in the patients with chronic alcoholism during the alcohol withdrawal symptoms as well as during the period remission.
In the case of the withdrawal symptoms in the patients, who suffer from addiction to benzodiazepines, Desyrel is effective in the treatment of anxiodepressive states and sleep disorders. Benzodiazepines can be replaced with Desyrel completely during the period of remission. The preparation helps to renew libido and potency in the patients with depression as well in the patients, who do not suffer from depression.
Desyrel does not build up a tolerance. It does not have an effect on a body weight.
Desyrel. What diseases does the preparation treat?
Desyrel is one of the most effective preparations in the treatment:
Anxiodepressive states of the endogenous nature (including involutional depression).
Psychogenic depressions (including reactive and neurotic depressions).
Anxiodepressive states in the setting of the organic CNS disorders (dementia, Alzheimer’s disease, cerebral atherosclerosis).
Depressed moods in the case of the long-term pain syndrome.
Disorders of libido and potency.
Desyrel. The Effectivness and Safe of Treatment
Strength of Desyrel in the treatment of the depressive disorders has been tested many times and has been compared with placebo and as well as with the most advanced antidepressants (imipramine, amitriptyline, desipramine, dozepinom, doxepin, mianserin, maprotiline, fluoxetine, bupropion, mirtazapine, venlafaxine, fluvoxamine and sertraline).
In most cases, Desyrel was, at least as effective as the medicine with which it was compared, and always Desyrel was more effective than placebo.
Safety of Desyrel is higher than the tricyclic antidepressants and, at least, comparable with the analogical measures of the newer antidepressants. Usually, Desyrel’s sedation is achieved rather quickly, so the medicine can be particularly useful for the patients in an infant state of treatment as the effective solution of a psychological support.
Due to the quick insomnia’s removal or relief in the patients with depression (besides alleviation of the other symptoms) the medicine provides compliance with treatment regimen, improves the patients’ performance during the day and improves the functional state of a body as a whole.
Desyrel. The Recommendations for Use
Desyrel is taken orally in 30 minutes before meals or in 2-4 hours after meal. The prescribed dose of tablet should be taken in one piece, not chewing and washing down with plenty of water.
The adults have to administrate the medicine in an initial dose of 100 mg 1 time/day after meal before bed. The dose can be increased up to 150 mg on the 4th day. Further, in order to achieve an optimal therapeutic effect, the dose can be increased up to 50 mg/day every 3-4 days, until an optimal dose is found.
A daily dose of 150 mg should be divided into 2 doses, at that the smaller dose should be taken after dinner, the main dose – at bedtime. The maximum daily dose for outpatients is 450 mg. The maximum daily dose for hospital patients is 600 mg.
To treat the disorders of libido – the recommended daily dose is 50 mg.
To treat the impotence – the recommended daily dose is 200 mg
As a combination therapy – the recommended daily dose is 50 mg.
To treat benzodiazepine dependence – the recommended treatment regimen is based on a gradual (sometimes for several months) reducing of the benzodiazepines’ dose. Reducing the dose of benzodiazepines for 1/4 or 1/2 tablet each time, 50 mg of Desyrel is added at the same time. This balance should be left unchanged for three weeks then there should be a further gradual reduction of the benzodiazepines’ dose up to their complete withdrawal. After, there should be reduction of the daily dose of Desyrel per 50 mg every 3 weeks.
For the elderly and the hyposthenic patients the initial dose is 100 mg/day in the divided doses or 1 times/day at bedtime. The dose may be increased under the care of a physician, depending on the drug efficacy and tolerance. Usually there is no need in dose, exceeding 300 mg/day.
The children aged 6-18 years: the initial daily dose is 1.5-2 mg/day, divided into several administrations. If necessary the dose can be gradually increased up to 6 mg/day 3-4 days apart.
Rate of administration
|1-3 days||50 mg in the evening (=1/3 tabs)||
Insomnia’a quality improvement
|4-6 days||100 mg in the evening (=2/3 tabs)||
|7-14 days||150 mg in the evening (1= tab)||
|from the 15th day||Following the dose or its increase up to 300 mg (=2 tabs)
At that, 100 mg (=2/3 tabs) is taken ~ 16:00 + 200 mg(=1 or 1/3 tabs) in the evening
Desyrel. The Feedbacks
What is good – the medicine relieves sexual side effects that many other antidepressants give (I’m talking about decreased libido, impaired erection and all these bad things.) Men will understand me: after Desyrel’s taking all “work” excellent))) You do not to drink any Viagra – and it is so perfectly)
Austin, 27 y.
I had severe depression plus scary psychic tension. I took many medicines. I came to the point that I began to take several drugs together (neuroleptics and several antidepressants). When I added Desyrel to my “diet”, I felt relief. Exhausting anxiety, apathy and impaction gradually disappeared.
Kelly, 38 y.
I did not want to live, the things were gloomy and hopeless …. In a week when I started to take Desyrel, the things began to improve. Light “glimmered” at the end of the tunnel. And in a month I felt great!
Lesley, 25 y.