Drospirenone Ethinyl Estradiol


Drospirenone (ethinyl estradiol) is the first drug in oral contraceptive that is taken in a 24 +4, that combines 24 days of receiving the active hormone pills plus 4 days of placebo. Innovative dosing regimen designed to avoid fluctuations in the level of female hormones that remain in the traditional mode of reception 7/ 21 (21 active hormone tablets plus 7 days off or 7 days placebo tablets).
The new regimen provides 3 additional days of drospirenone and affirmative action leads to minimization of fluctuations in hormone levels. This eliminates the associated negative symptoms – anxiety, irritability, mood changes, impaired concentration, swelling, headache, breast engorgement, etc. Due to the content of the preparation of such a component, as drospirenone, in particular its antimineralocorticoid properties, the body does not stay liquid (due to the estrogen component), and therefore such symptoms as swelling, weight gain, bloating, breast engorgement do not develop.

Finally, the anti-androgenic properties of drospirenone provide a positive effect on the skin, reducing the activity of the sebaceous glands and as a result, achieved a therapeutic effect in acne.

Drospirenone exhibits no androgenic, estrogenic, glucocorticoid and antiglucocorticoid activity, which in combination with antimineralocorticoid and antiandrogenic properties indicates the similarity of the pharmacological profile of drospirenone and natural hormone progesterone.
In two multicenter, double-blind, randomized, placebo-controlled studies of efficacy and safety of the drug in women with drospirenone acne vulgaris of mild and severe, it was demonstrated clinically and statistically showed significant effect relative to the primary treatment success rates (number of inflammatory and noninflammatory elements, the total number of lesions (elements) and the number and proportion of women with a clear skin, which was assessed on a scale of ISGA (Investigator `s Stated Global Assessment – evaluation scale general state of the researcher), and the majority of secondary indicators.

Thanks to all of the above Drospirenone (ethinyl estradiol) is the only oral contraceptive approved in the country to apply for three indications:
    • Prevention of unwanted pregnancies,
    • treatment of acne (acne) and mild to moderate severity,
    • treatment of emotional and physical symptoms of menstruation period, including the most severe manifestation of them – premenstrual dysphonic disorder (PMDD).

Mode of the drug Drospirenone 24 +4 scheme provides:

  •       Abridged non hormonal intervals
  •       Decrease hormonal fluctuations
  •       Prevention of premenstrual disorders

· Improvement of the skin
Daily admission procedure: due to a placebo pill it is easier to keep track of when to start the next pack Drospirenone (ethinyl estradiol).
Safe and practical:
The company has taken care about the convenience, comfort and safety of a new contraceptive drug Drospirenone (ethinyl estradiol):
    *Each blister pack with Drospirenone (ethinyl estradiol) contraceptive introduced in new packaging, that is in a convenient "envelope", which is comfortably housed in a purse or clutch. Thus, women and girls do not have to hide their pills in the box, and then get them out of it.
    *On one side of "envelope" there is applied the so-called "Rule of the forgotten pills," which will give advice and tell you what to do in case of contraceptive pills Drospirenone reception was omitted, as well as when to take it up next time and what the consequences of such forgetfulness can trap you. Thanks to a new type of packaging as a "purse" is now no need to constantly carry the instructions for use.

In addition, Drospirenone provides reliable protection from unwanted pregnancy; it has also a positive impact on skin condition and general psycho-emotional and physiological state of a woman. The combination of drospirenone with ethinylestradiol improves the content of high-density lipoprotein cholesterol, which favorably affects the cardiovascular system. Thus, according to professors, composition and a unique mode of drug administration Drospirenone can be used not only as a medium of contraception, but also for long-term use in most healthy women until the late reproductive age.

Dosage and administration:
Tablets should be taken daily according to the order specified on the blister, about the same time, with a small amount of liquid. Interruption in the application of tablets Drospirenone does not include. The drug is taken by one tablet per day for 28 days. Tablets from each of the next pack should be started after taking the last pill from the previous package. Menstrual bleeding usually begins at the third day of the placebo pills and can not finish by the beginning of the pills the next pack.

If hormonal contraceptives in the previous period (last month) was not used the tablets should be initiated in 1-day woman’s natural cycle (ie the 1st day of menstrual bleeding). You can start receiving and 5 days, but in this case in the first cycle is recommended to additionally use like a barrier method of contraception for the first 7 days of treatment.

Switching from another combined oral contraceptive (CPC), vaginal ring or transdermal patch is desirable that the woman should start taking the pill Drospirenone on the day after taking the last active pill the previous PDA, but not later than the day after a break in tablet or pill placebo after receiving her previous PDA. In the case of a vaginal ring or transdermal patch is desirable that the woman should start taking Drospirenone to that day, in any case not later than the day when you need the following use of these devices.

Go with a method that is based on the use of only a progestogen ("mini-pill", injections, implants) or intrauterine system with progestogen woman can begin taking the drug Drospirenone every day after discontinuation of the "mini-pill" (in the case of an implant or intrauterine system – on the day of their removal, in the case of injections – rather than following injection). However, in all cases it is recommended to additionally use like a barrier method of contraception for the first 7 days of treatment. Try it and you’ll never regret!

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