Identification of T. pallidum from lesions using darkfield microscopy

Identification of T. pallidum

 

 

DIAGNOSIS

There is no gold standard and no culture technique is available. Diagnosis must rely on the following:

Clinical manifestations

Identification of T. pallidum from lesions using darkfield microscopy

  1. Serology

Nontreponemal.

It measures immunoglobulin M (IgM) and immunoglobulin G (IgG) antibody directed against cardiolipin—lecithin- cholesterol antigen.

It is nonspecific for T. pallidum.

It is used to determine antibody titer and monitor therapy. Rising titer indicates an active infection that may be any one of the following:

New infection

Reinfection

Reactivation of the latent disease

Types of tests include the following:

Venereal Disease Research Laboratory (VDRL)

Rapid plasma reagin (RPR)

Treponemal

Measures IgM and IgG antibody against T. pallidum— specific antigens

Types are as follows: –

Fluorescent treponemal antibody test (FTA-ABS).

  1. pallidum—hemogiutinatisag antibody tests (MHA-TP, TPHA)
  2. Specific treponemal antibody tests may remain active after adequate therapy.

 

Be the first to comment on "Identification of T. pallidum from lesions using darkfield microscopy"

Leave a comment

Your email address will not be published.


*