PREMARIN tablets: drug description.

Premarin is a conjugated estrogens tablets. It is a mixture of estrogen hormones which are essential for female system. Conjugated estrogens used in medicine to manage symptoms associated with a menopause such are vaginal burning, dryness and itching, hot flashes, mood swings etc. Also the drug can be used to treat osteoporosis. Conjugated estrogens used by woman to improve their female function due to castration, ovarian failure or underdevelopment of hormone-secreting organs (hypogonadism). Conjugated estrogens also used in treating prostate cancer and breast cancer.



Tell your doctor if you have any of the following conditions before taking PREMARIN:

  • heart disease, high blood pressure, or circulation problems;
  • high or law level of calcium in the blood;
  • a personal or family history of stroke;
  • pregnancy;
  • endometriosis;
  • mental depression;
  • kidney or liver disease;
  • asthma;
  • epilepsy or other seizure disorder;
  • porphyria;
  • migraines;
  • endometrial, cervical,  breast, ovarian or uterine cancer;
  • diabetes;
  • underactive thyroid;
  • if you smoke;
  • high cholesterol or triglycerides;
  • high or low levels of calcium in your blood;
  • systemic lupus erythematosus (SLE);
  • gallbladder disease;
  • if you have had your uterus removed (hysterectomy);
  • if you are breastfeeding.

The drugs which may interact with conjugated estrogens

• warfarin
• letrozole
• cyclosporine
• some antibiotics used to treat infections
• bromocriptine

• raloxifene or tamoxifen
• carbamazepine
• dantrolene
• exemestane
• medications for diabetes
• methotrexate
• griseofulvin
• hydrocortisone, cortisone, or prednisolone
• isoniazid (INH)
• methotrexate
• phenytoin
• raloxifene or tamoxifen
• testolactone
• thyroid hormones
• topiramate
• tricyclic antidepressants

• mineral oil

• anastrozole

• rifabutin, rifampin, or rifapentine
• barbiturates or benzodiazepines used for inducing sleep or treating seizures (convulsions)


How to take PREMARIN

Please read carefully prescription label before taking the drug. Make sure that everything written there is clear to you. Conjugated estrogen must be taken orally with water or food. Try to take the drug at the same time every day and as often as directed in prescription label.

If you going to use this medication on children contact your pharmacist before doing this. There is could be special care essential.


In case you miss a dose

If you miss your dose you should take it as soon as possible. But you shouldn’t take an extra o double dose even if it is time for next one.

If you are taking any other medicines including non-prescription ones, herbal products, nutritional supplements, you should tell this to your doctor or pharmacist. Also they must know if you smoke, taking caffeine and illegal drugs because in this case the result of taking PREMARIN can be different.  If you are going to start or stop using any medicines please check it up with your health care provider.


Side effects that may occur from taking conjugated estrogens


Common side effects of conjugated estrogens include:

  • swelling of the hands, feet or ankles
  • weight gain
  •  vision or speech problems
  •  confusion, forgetfulness
  •  shortness of breath
  •  chest ache
  •  stomach pain (severe)
  • yellowing of the eyes or skin
  •  headaches
  •  leg, arm or groin ache
  • breakthrough bleeding and spotting
  •  breast enlargement, tenderness, unusual discharge or milk production
  •  nausea, vomiting


If you get following side effects they are usually do not require medical attention. But if they continue tell about this to your doctor

• weight gain

• increased or decreased appetite
• urinary incontinence
• mood changes, depression, anger, anxiety, frustration, emotional outbursts

• change in sexual desire
• mild stomach upset
• skin rash, acne, or brown spots on the face
• tiredness
• irritation and white discharge in vagina



The most important information you should know about PREMARIN


Estrogens increase the chance of getting cancer of the uterus.

Report any unusual vaginal bleeding straight away while you are using these products. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus. Your health care provider should check any unusual vaginal bleeding to find out the cause.

To prevent heart disease, heart attacks, strokes, or dementia do not use estrogens with or without progestin, strongly do not smoke.

While taking conjugated estrogens, there are no limitations on food, drinks, or activity unless your doctor gives you such recommendations. Pregnant women should not take estrogens because they can be harmful to the fetus. . Women who are breast-feeding should not take this medication. Estrogens penetrate into breast milk and their effects in the infant are unpredictable.

You and your health care provider should talk regularly about whether you still need treatment with estrogens.
Using estrogens, with or without progestin, may increase your chance of getting heart attacks, strokes, breast cancer, and blood clots. Using estrogens, with or without progestin, may increase your chance of getting dementia, based on a study of women age 65 years or older.

If you notice visual changes wearing contact lenses or if you start to feel uncomfortable wearing them, ask your eye care specialist for advice or report this to your health care professional.

If you about to have elective surgery, you may need to stop taking PREMARIN one month before that. For advice according to scheduling the surgery consult your health care professional.

Your fingers, hands, or ankles can get swelled while you taking conjugated estrogens. If you feel that your blood pressure goes up you must contact your health care professional

Regularly visit your doctor or health care professional for check-ups on your progress while taking the drug. You better make these visits every 6 months. While on conjugated estrogens therapy you will need a regular breast and pelvic exam and ‘Pap’ smear. Regular mammograms are essential as well as the guldens of specialist.



How you should keep PREMARIN

Keep Conjugated Estrogens at room temperature between 15-30 degrees C (59-77 degrees F) out of reach of children.

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