Why CLOMID does not work?


According to statistics, nearly 75% of women who take CLOMID (with CLOMIPHENE citrate as an active substance) get positive results and the ovulation, and other 25% don’t. There may be several reasons for it.

One of the possible reasons is the low dosage of CLOMID. Usually the patients start from 50 mg, and then increase the dosage if there’re no results. It can be increased to 100-150 mg, and sometimes even to 250 mg, but one should avoid it to prevent side effects. Some patients are CLOMIPHENE resistant. Among CLOMID-resistant patients can be:

–         women who have hyperandrogenic levels (taking birth control pills before CLOMID for a month or two may help)

–         women who are insulin resistant (a drug Metformin, or Glucophage can help such patients)

–         women who have a body mass index more than 25 (they should lose some weight and then try CLOMIPHENE again)

–         women with hyperprolactinemia (in this case ovulation rates can be improved with the help of the Bromocriptine drug)

But there may be other reasons. Sometimes taking other additional medicines can be prescribed, with or without CLOMID.

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